Selective Inhibition of BFL1: It’s All about Finding the Right Partner

Finding the Right Partner: Science or ART?

In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008) now identify an arrestin-related family of Rsp5 adaptor proteins called ARTs that confer specificity on the ubiquitination of plasma membrane proteins and contribute to the ma...

Finding Risk in All the Right Places

In this issue of Neuron, Cruchaga et al. (2013) identify genetic variability linked to altered levels of tau protein in cerebrospinal fluid. They show that the same genetic variants can also confer risk for Alzheimer's disease.

Partner Selection - Finding the Right Combination of Players

In games that model cooperative dilemmas, if players are able to choose with whom they will play, they will seek out cooperative partners while escaping free riders. In this paper we recast the problem of selecting with whom to play as a problem of finding the right combination of players. With this approach, we present a model suitable to any n-player game. The model is adaptive and we present...

Are We Asking All the Right Questions About Quality of Care in Low- and Middle-Income Countries?

Finding the right balance of BRAF inhibition in melanoma.

Paradoxical activation of the mitogen-activated protein kinase pathway can cause secondary malignancies in patients treated with inhibitors of BRAF(V600) proteins. Characterization of a patient with concurrent BRAF-mutant melanoma and NRAS-mutant leukemia treated intermittently with combined BRAF and MEK inhibition provides new insights into the potential clinical and molecular effects of this ...